Classification of Drugs used in Diuretics

Definition of Diuretics

Diuretics (natriuretics) are drugs which cause a net loss of Na+ and water in urine. However, Na+ balance is soon restored, even with continuing diuretic action, by compensatory homeostatic mechanisms of the body, albeit with a certain degree of persisting Na+ deficit and reduction in extracellular fluid volume.


High efficacy diuretics(inhibitors of Na+ – K+ – 2Cl- cotransport)

Sulphamoyl derivatives

  • Furosemide
  • Bumetanide
  • Torasemide

Medium efficacy diuretics(Inhibitors of Na+ , Cl- symport)


  • Hydrochlorothiazide
  • Benzthiazide
  • Hydroflumethiazide

Thiazide like

  • Clopamide
  • Xipamide
  • Indapamide
  • Metolazone
  • Chlorthalidone

Weak or adjunctive diuretics

Carbonic anhydrase inhibitors

  • Acetazolamide

Potassium sparing diuretics

Aldosterone antagonist:

  • Spironolactone
  • Eplerenone

Inhibitors of renal epithelial Na+ channel:

  • Amiloride
  • Triamterene

Osmotic diuretics

  • Mannitol
  • Glycerol
  • Isosorbide

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